List of Approved Clinical Trials in Tanzania:
S/N Study Title Condition Intervention Principal Investigator Location Sponsor
1. A Phase 2B Study to Evaluate the Safety and Efficacy of VRC01 broadly neutralising monoclonal antibody in reducing acquisition of HIV-1 infection. (HVTN 703/HPTN081) HIV VRC01 Dr. Lucas maganga NIMR - MMRC P.O. Box 2410, Mbeya, Tanzania NIMR-MMRC Division of AIDS, National Institute of Allergy and Infectious Diseases US department of Health and Human Services
2. A Side by Side Comparison of Transvaginal Colposcope to Standard of Care Cervicography in a 50 - patients pilot study on women undergoing cervical cancer screening Cervical Cancer Transvaginal Digital Colposcope Dr. Olela Oneko KCMC DUKE UNIVERSITY
3. Dyadic Based Diagnosis, Care & Prevention HIV Discondant Couple in Tanzania HIV HIV-Test Kits (Oral Quick Rapid HIV 12 Antibody Assay) Dr. Jessie Mmbwambo MNH-MUHAS National Institute Mental Health NIMH-USA
4. A dose reduction Immunobridging and Safety Study of Two HPV Vaccine in Tanzanian Girls Cervical Cancer Cervarix™ and Cardasil-9® (HPV Prophylactic Vaccines) Dr John Changalucha MITU Mwanza London School of Hygiene and Tropical Medicine
5. IMPAACT P1026s: Pharmacokinetic Properties of Antiretroviral and Related Drugs During Pregnancy and Postpartum HIV No ARV drugs/ Drugs Combination, TB drugs or Contraceptive Agents James samwel Ngocho KCMC National Institute of Health (NIH)-US
6. Febrile Illnes Survilence in Northen Tanzania Infectiuous disease dignostic tool Film Array Instrument Dr Venance Maro KCMC National Institute of Health (NIH)-US
7. Randomized clinical trial to assess whether the duration of cotrimoxazole preventive therapy in HIV patients with CD4 counts less tha 350 cells/ul by antiretroviral treatment influences the rate of carriage of multdrug-resistant bacteria HIV Co-trimoxazole tablet Dr Joel Manyahi MUHAS MUHAS/NORWAY UNIVERSITY
9. An evaluation of a combination HIV prevention intervention that includes oral PrEP for adolescent girl and young women in south africa and tanzania HIV TRUVADA(for HIV pre exposure prophilaxis Dr saidi Kapinga Mwanza Intervention Trial Unit: NIMR, Mwanza.(MITU) Wits Health Consortum (Pty) Ltd, South Africa
10. A MULT-COUNTRY PROSPECTIVE CLINICAL SAFETY OF SUBJECTS EXPOSED TO THE CANDIDATE EBOLA VACCINE Ad26.ZEBOV and /or MVA-BN-Filo EBOLA Grdasil 9R Dr George PrayGod Mwanza Intervention Trial Unit: NIMR, Mwanza.(MITU) Crucell Holand BV Johnson Pharmaceutical
11. Antibiotics for Children with Severe Diarrhea (ABCD) Trial Ciprofloxacin and Azithromycin Professor Karim P. Manji Mbagala Rangitatu, Mbagala Round table, Temeke, Mwananyamala and Amana District hospitals. Additionally, Recruitment will be done from Muhimbili National Hospital outpatient as well World Health Organization (WHO)
12. Establishing the optimal dose of therapeutic zinc supplementation for the treatment of acute diarrhea in under five children – a dose response trial in South Asian and a Sub-Saharan African Setting (aka ZTDT) Elemental Zinc Sulphate - 5mg and 10 mg Professor Karim P Manji These sites are large district hospitals in Dar es Salaam and we have conducted multiple studies and clinical trials. World Health Organization (WHO)
13. Field Trial evaluate the effect of the TSOL18(11L) and oxfendazole(30mg/kgParanthic 10% TSOL18(11L) and oxfendazole(30mg/kgParanthic 10% Hellen Ngowi Mbeya and mbozi district GALVmed
14. IMPAACT 2010 Phase III Study of virologic efficacy and safety of Dolutegravir containing versus efavirenz-containing Antiretroviral therapy Regimens in HIV-1-Infected Pregnant Women and theire Infants Versin 1.0, 1 December 2016 HIV Dolutegravir Dr James Samwel Ngocho KCMC-Duke University AIDS Collaboration, P.O.Box 3010 MOSHI National insitute of Allergy and infectious diseases and NICHD
15. INVICTUS Trials Investigation of rheumatic Atrial Fibrillation Treatment using vitamin K anatgonists, rivaroxaban or Aspirin Studies Rivaroxaban Dr. Pilly 1) MUHAS Academic Medical Centre 2) JKCI 3) Dodoma Hospital 4) Mbeya Hospital Hamilton Health Sciences, Hamilton, ON, Canada.
16. IPTp with dihydroartemisinin-piperaquine and azithromycin for malaria, sexually transmited and reproductive tract infections in pregnancy in high sulphadoxine-pyrimethamine resistance area in kenya,malawi and tanzania an inernational multcenter 3-arm placebo-controlled trial MALARIA dihydroartemisinin-piperaquine and azithromycin Prof John Lusingu(korogwe-TZ) NIMR-KOROGWE Liverpool school of tropical medicine(LSTM)
17. ELICIT Early life intervention for childhood growth and development in TANZANIA Vit b3. Azithromycine and Nilazoxamide Estimith Mduma Hydom-Global Health Research Centre Timothe Burra P.O.Box 9000 Hydom manyara
18. A phase 1/2a clinical trial to evaluate the safety and immunogenicity of ALVAC-HIV (Vcp2438) and MF50®-or AS01B -adjuvanted clade C Env protein, in healthy, HIV-Uninfected adult participants (HVTN 120) HIV ALVAC-HIV (Vcp2438) and MF50®-or AS01B -adjuvanted clade C Env protein Dr. Winstom William mmrc-nimr-mbeya Division of AIDS, National Institute of Allergy and Infectious Diseases US department of Health and Human Services
19. Aiming at prolonging the therapeutic life span of artemisinin-based combination therapies in an era of imminent Plasmodium falciparum resistance in Bagamoyo District, Tanzania - new strategies with old tools Artemether-Lumefantrine and Primaquine Dr. Lwidiko Edward Mhamilawa Telephone: +255712865206 Fax: E-mail: Bagamoyo District, Tanzania. Muhimbili University of Health and Allied Sciences; Dept. of Parasitology and Medical Entomology P. O. Box 65001 Upanga, Dar es salaam Tanzania, Karolinska Institutet, Dept of Molecular, Tumor and Cell Biology, Nobelsväg 16 171 77 Stockholm, Sweden Uppsala University, Dept. of Women's and Children's Health, IMCH, Drottninggatan 4, 75310 Uppsala Sweden
20. IMPAACT 2005: A phase I/II open-label, single-arm study to evaluate the pharmacokinetics, safety and tolerability of Delamanid in combination with optimized multidrug background Regimen (OBR) for Multi-Drug resistant Tuberculosis (MDR-TB)in HIV-infected and HIV-Uninfected children with MDR-TB TB Delamanid Dr. Cynthia Asiyo KCMC national institute of child health and human development (NICHD)
21. Cepheid Genexpent omni combined with the Xpert MTB/RIF utra for detection of tuberculosis and Rifampicin resistance in adults with preventive pulmonary tuberculosis at primary level diagonostic Centre in Tanzania,a pragnatic cluster,randomazed controlled trial(short tittle:Omni/Utra trial) TB Dr. Fredrick Haraka BAGAMOYO Foundation for Inovative new Diagnostics
22. The development and evaluation of informed HIV self testing intervention among hard to reach adults in Northern Tanzania(Dr. Bernad Njau) HIV Dr. Bernad Njau KCMC Duha global Health Institute,USA
23. Field trial to evaluate the safety and efficacy of cysvax™ recombinant porcine cysticercosis vaccine in pigs kept under field conditions in Tanzania Cysticercosis Dr. Elisante Makundi USDM-babati and Hanang regions Global Alliance for veterinary Medicine
24. A Phase Ib age de-escalation dose-escalation randomised, double-blind, controlled study of the safety and immunogenicity of heterologous prime-boost with the candidate malaria vaccines ChAd63 RH5 and MVA RH5 administered intramuscularly according to a 0, 2-month vaccination schedule in healthy adults, young children and infants in Tanzania. malaria Dr. Ally Olotu Kingani Estate-IHI University of Oxford
25. Clinical Trial to evaluate the safety, immunogenicity and efficacy of direct venous inoculation of Plasmodium Falciparum sporozoite vaccine (PfSPZ vaccine) in HIV negative and HIV positive Tanzanian adults malaria Dr Said Jongo Bagamoyo Sanavia Inc. USA
26. The impact of intermittent preventive treatment strategies in reducing Malaria related morbidity and improving cognitive ability in school-aged children: A neglected Control domain with a considerable development Impact malaria Dr. Geofrey Makenga Teule Hospital Muheza District Global Health Institute (GHI)
27. Doxycycline 200mg/d vs 100mg/d for 6 weeks to improve filarial lymphedema - a multinational,double blind,randomized,Placebo-controlled trial Filarial lymphedema Dr. Upendo Mwingira NIMR National Institute for Malarial Research